/* ============================================
   MEDICAT — Design System
   Automating the Search for Rare Disease Cures
   ============================================ */

@import url('https://fonts.googleapis.com/css2?family=Crimson+Pro:ital,wght@0,300;0,400;0,500;0,600;0,700;1,300;1,400&family=JetBrains+Mono:wght@300;400;500&family=Inter:wght@300;400;500;600&display=swap');

/* --- View Transitions (smooth cross-page navigation) --- */
@view-transition {
  navigation: auto;
}

::view-transition-old(root) {
  animation: vt-fade-out 0.18s ease-out both;
}
::view-transition-new(root) {
  animation: vt-fade-in 0.22s ease-in both;
}

@keyframes vt-fade-out {
  from { opacity: 1; transform: translateY(0); }
  to   { opacity: 0; transform: translateY(-4px); }
}
@keyframes vt-fade-in {
  from { opacity: 0; transform: translateY(4px); }
  to   { opacity: 1; transform: translateY(0); }
}


/* --- Tokens --- */
:root {
  --bg:          #f5f2ec;
  --bg-warm:     #efe9df;
  --bg-card:     #faf8f4;
  --text:        #1a1a1a;
  --text-muted:  #6b6560;
  --text-light:  #9a9590;
  --accent:      #0d7377;
  --accent-glow: #10918a;
  --accent-soft: rgba(13,115,119,0.08);
  --border:      #d5d0c8;
  --border-light:#e5e0d8;
  --danger:      #c0392b;
  --success:     #27ae60;
  --warning:     #e67e22;

  --font-serif:  'Crimson Pro', 'Georgia', serif;
  --font-sans:   'Inter', -apple-system, sans-serif;
  --font-mono:   'JetBrains Mono', 'Fira Code', monospace;

  --max-width:   960px;
  --header-h:    56px;
  --radius:      6px;
  --transition:  0.25s cubic-bezier(0.4, 0, 0.2, 1);
}

/* --- Reset --- */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }

html {
  font-size: 17px;
  scroll-behavior: smooth;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

body {
  font-family: var(--font-serif);
  background: var(--bg);
  color: var(--text);
  line-height: 1.7;
  min-height: 100vh;
  overflow-x: hidden;
}

/* Vignette overlay */
body::before {
  content: '';
  position: fixed;
  inset: 0;
  pointer-events: none;
  z-index: 9999;
  background: radial-gradient(ellipse at center, transparent 60%, rgba(13,115,119,0.03) 100%);
}

/* --- Typography --- */
h1, h2, h3, h4 {
  font-family: var(--font-serif);
  font-weight: 400;
  letter-spacing: -0.01em;
  line-height: 1.25;
}

h1 { font-size: 2.8rem; }
h2 { font-size: 1.5rem; color: var(--text-muted); margin-bottom: 1.5rem; }
h3 { font-size: 1.15rem; font-weight: 500; }

p { margin-bottom: 1rem; }

a {
  color: var(--accent);
  text-decoration: none;
  transition: color var(--transition);
}
a:hover { color: var(--accent-glow); }

.label {
  font-family: var(--font-sans);
  font-size: 0.7rem;
  font-weight: 600;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--text-light);
}

.mono {
  font-family: var(--font-mono);
  font-size: 0.85rem;
}

/* --- Header / Nav --- */
.site-header {
  position: fixed;
  top: 0;
  left: 0;
  right: 0;
  height: var(--header-h);
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 0 2rem;
  background: rgba(245,242,236,0.85);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
  border-bottom: 1px solid var(--border-light);
  z-index: 1000;
  transition: background var(--transition);
}

.site-logo {
  font-family: var(--font-sans);
  font-size: 0.75rem;
  font-weight: 600;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--text);
  text-decoration: none;
  display: flex;
  align-items: center;
  gap: 0.5rem;
}
.site-logo img {
  height: 32px;
  width: auto;
  mix-blend-mode: multiply;
}
.site-logo:hover { color: var(--accent); }

.site-nav {
  display: flex;
  align-items: center;
  gap: 1.8rem;
}

.site-nav a {
  font-family: var(--font-sans);
  font-size: 0.75rem;
  font-weight: 400;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  text-decoration: none;
  transition: color var(--transition);
  position: relative;
}
.site-nav a::after {
  content: '';
  position: absolute;
  bottom: -2px;
  left: 0;
  width: 0;
  height: 1px;
  background: var(--accent);
  transition: width var(--transition);
}
.site-nav a:hover { color: var(--text); }
.site-nav a:hover::after { width: 100%; }
.site-nav a.active { color: var(--accent); }
.site-nav a.active::after { width: 100%; }

.nav-cta {
  font-family: var(--font-sans) !important;
  font-size: 0.7rem !important;
  font-weight: 500 !important;
  padding: 0.45rem 1rem;
  border: 1px solid var(--accent);
  border-radius: 3px;
  color: var(--accent) !important;
  transition: all var(--transition);
}
.nav-cta:hover {
  background: var(--accent);
  color: #fff !important;
}
.nav-cta::after { display: none !important; }

.header-right {
  display: flex;
  align-items: center;
  gap: 1.5rem;
}

.header-x-btn {
  display: inline-flex;
  align-items: center;
  gap: 0.45rem;
  padding: 0.4rem 0.85rem;
  background: var(--text);
  color: var(--bg) !important;
  border-radius: 20px;
  font-family: var(--font-sans);
  font-size: 0.75rem;
  font-weight: 600;
  text-decoration: none;
  transition: all var(--transition);
  box-shadow: 0 2px 6px rgba(0,0,0,0.12);
}
.header-x-btn svg {
  fill: currentColor;
  width: 12px;
  height: 12px;
  flex-shrink: 0;
}
.header-x-btn:hover {
  background: var(--accent);
  color: #ffffff !important;
  transform: translateY(-1px);
  box-shadow: 0 4px 10px rgba(0,0,0,0.18);
}

/* Mobile nav toggle */
.nav-toggle {
  display: none;
  background: none;
  border: none;
  cursor: pointer;
  padding: 0.5rem;
}
.nav-toggle span {
  display: block;
  width: 20px;
  height: 1.5px;
  background: var(--text);
  margin: 4px 0;
  transition: var(--transition);
}

/* --- Main Content --- */
main {
  padding-top: calc(var(--header-h) + 3rem);
  max-width: var(--max-width);
  margin: 0 auto;
  padding-left: 2rem;
  padding-right: 2rem;
  padding-bottom: 6rem;
}

/* --- Hero --- */
.hero {
  padding: 4rem 0 3rem;
  text-align: left;
}

.hero-badge {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.35rem 0.9rem;
  background: var(--accent-soft);
  border: 1px solid rgba(13,115,119,0.15);
  border-radius: 20px;
  margin-bottom: 2rem;
}
.hero-badge .pulse {
  width: 6px;
  height: 6px;
  border-radius: 50%;
  background: var(--accent);
  animation: pulse 2s ease-in-out infinite;
}
.hero-badge span {
  font-family: var(--font-sans);
  font-size: 0.68rem;
  font-weight: 500;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--accent);
}

@keyframes pulse {
  0%, 100% { opacity: 1; transform: scale(1); }
  50% { opacity: 0.4; transform: scale(0.8); }
}

.hero h1 {
  margin-bottom: 1.5rem;
  max-width: 700px;
}

.hero-subtitle {
  font-size: 1.15rem;
  color: var(--text-muted);
  max-width: 620px;
  line-height: 1.8;
  margin-bottom: 2.5rem;
}

.hero-actions {
  display: flex;
  gap: 1rem;
  flex-wrap: wrap;
}

.btn {
  font-family: var(--font-sans);
  font-size: 0.75rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  padding: 0.65rem 1.5rem;
  border-radius: 3px;
  text-decoration: none;
  transition: all var(--transition);
  cursor: pointer;
  border: none;
}

.btn-primary {
  background: var(--accent);
  color: #fff;
}
.btn-primary:hover {
  background: var(--accent-glow);
  color: #fff;
  transform: translateY(-1px);
  box-shadow: 0 4px 12px rgba(13,115,119,0.2);
}

.btn-outline {
  background: transparent;
  color: var(--text-muted);
  border: 1px solid var(--border);
}
.btn-outline:hover {
  border-color: var(--accent);
  color: var(--accent);
}

/* --- Stats Grid --- */
.stats-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  overflow: hidden;
  margin: 3rem 0;
  background: var(--bg-card);
}

.stat-cell {
  padding: 1.5rem 1.2rem;
  border-right: 1px solid var(--border-light);
  display: flex;
  flex-direction: column;
  gap: 0.3rem;
}
.stat-cell:last-child { border-right: none; }

.stat-value {
  font-family: var(--font-serif);
  font-size: 1.8rem;
  font-weight: 300;
  color: var(--text);
  line-height: 1.1;
}

.stat-label {
  font-family: var(--font-sans);
  font-size: 0.68rem;
  font-weight: 400;
  letter-spacing: 0.04em;
  color: var(--text-light);
  line-height: 1.4;
}

/* --- Sections --- */
.section {
  padding: 3rem 0;
  border-top: 1px solid var(--border-light);
}

.section-number {
  font-family: var(--font-sans);
  font-size: 0.68rem;
  color: var(--text-light);
  margin-bottom: 0.5rem;
  letter-spacing: 0.05em;
}

.section p {
  color: var(--text-muted);
  max-width: 680px;
}

/* --- Disease Cards (diseases page) --- */
.disease-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
  gap: 1px;
  background: var(--border-light);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  overflow: hidden;
  margin: 2rem 0;
}

.disease-card {
  background: var(--bg-card);
  padding: 1.5rem;
  cursor: pointer;
  transition: background var(--transition);
  position: relative;
}
.disease-card:hover { background: #fff; }

.disease-card-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  margin-bottom: 0.75rem;
}

.disease-name {
  font-family: var(--font-serif);
  font-size: 1.05rem;
  font-weight: 500;
  color: var(--text);
}

.disease-badge {
  font-family: var(--font-sans);
  font-size: 0.6rem;
  font-weight: 600;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  padding: 0.2rem 0.5rem;
  border-radius: 2px;
}
.badge-no-treatment {
  background: rgba(192,57,43,0.08);
  color: var(--danger);
}
.badge-in-trial {
  background: rgba(230,126,34,0.08);
  color: var(--warning);
}
.badge-control {
  background: rgba(39,174,96,0.08);
  color: var(--success);
}

.disease-meta {
  font-family: var(--font-mono);
  font-size: 0.72rem;
  color: var(--text-light);
  line-height: 1.6;
}

.disease-gene {
  color: var(--accent);
  font-weight: 500;
}

/* --- Live Solver --- */
.solver-container {
  display: grid;
  grid-template-columns: 1fr 280px;
  gap: 1px;
  background: var(--border);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  overflow: hidden;
  min-height: 70vh;
  margin: 2rem 0;
}

.solver-main {
  background: #1a1a1a;
  padding: 1.5rem 2rem;
  overflow-y: auto;
  position: relative;
}

.solver-main::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 40px;
  background: linear-gradient(to bottom, #1a1a1a, transparent);
  z-index: 1;
  pointer-events: none;
}

.solver-transcript {
  font-family: var(--font-mono);
  font-size: 0.78rem;
  line-height: 1.8;
  color: #c8c8c0;
  white-space: pre-wrap;
  word-break: break-word;
}

.solver-transcript .label-known {
  color: #6bba75;
  font-weight: 500;
}
.solver-transcript .label-inferred {
  color: #e8b84a;
  font-weight: 500;
}
.solver-transcript .label-hypothetical {
  color: #e07a5f;
  font-weight: 500;
}
.solver-transcript .label-section {
  color: #8ab4f8;
  font-weight: 500;
}

.solver-cursor {
  display: inline-block;
  width: 7px;
  height: 14px;
  background: var(--accent);
  animation: blink 1s step-end infinite;
  vertical-align: middle;
  margin-left: 2px;
}
@keyframes blink {
  50% { opacity: 0; }
}

.solver-sidebar {
  background: var(--bg-card);
  padding: 1.5rem;
  display: flex;
  flex-direction: column;
  gap: 1.5rem;
}

.solver-status {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.5rem 0.75rem;
  background: rgba(13,115,119,0.06);
  border: 1px solid rgba(13,115,119,0.12);
  border-radius: 3px;
}
.solver-status .dot {
  width: 6px;
  height: 6px;
  border-radius: 50%;
  background: var(--accent);
  animation: pulse 2s ease-in-out infinite;
}
.solver-status span {
  font-family: var(--font-sans);
  font-size: 0.68rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
}

.sidebar-section { }
.sidebar-section .label { margin-bottom: 0.5rem; }
.sidebar-value {
  font-family: var(--font-serif);
  font-size: 0.95rem;
  color: var(--text);
  line-height: 1.5;
}
.sidebar-meta {
  font-family: var(--font-mono);
  font-size: 0.7rem;
  color: var(--text-light);
  margin-top: 0.25rem;
}

.disease-selector {
  list-style: none;
}
.disease-selector li {
  font-family: var(--font-sans);
  font-size: 0.75rem;
  padding: 0.45rem 0.6rem;
  border-radius: 3px;
  cursor: pointer;
  color: var(--text-muted);
  transition: all var(--transition);
  display: flex;
  align-items: center;
  gap: 0.5rem;
}
.disease-selector li:hover { background: var(--accent-soft); color: var(--text); }
.disease-selector li.active {
  background: var(--accent-soft);
  color: var(--accent);
  font-weight: 500;
}
.disease-selector li .selector-dot {
  width: 4px;
  height: 4px;
  border-radius: 50%;
  background: var(--border);
  flex-shrink: 0;
}
.disease-selector li.active .selector-dot {
  background: var(--accent);
}

/* --- Docs --- */
.doc-section {
  padding: 2rem 0;
  border-top: 1px solid var(--border-light);
}

.doc-section h3 {
  margin-bottom: 1rem;
}

.doc-callout {
  background: var(--accent-soft);
  border-left: 2px solid var(--accent);
  padding: 1rem 1.2rem;
  border-radius: 0 var(--radius) var(--radius) 0;
  margin: 1.5rem 0;
}
.doc-callout p {
  color: var(--text);
  margin: 0;
  font-size: 0.95rem;
}

.code-block {
  background: #1a1a1a;
  border-radius: var(--radius);
  padding: 1.2rem 1.5rem;
  margin: 1.5rem 0;
  overflow-x: auto;
}
.code-block code {
  font-family: var(--font-mono);
  font-size: 0.78rem;
  line-height: 1.7;
  color: #c8c8c0;
}

/* --- Footer --- */
.site-footer {
  border-top: 1px solid var(--border);
  padding: 3rem 2rem;
  max-width: var(--max-width);
  margin: 0 auto;
}

.footer-grid {
  display: grid;
  grid-template-columns: 2.2fr 1fr 1fr 1.6fr;
  gap: 2rem;
  margin-bottom: 2.5rem;
}

.compute-list {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--text-muted);
  list-style: none;
}
.compute-list li {
  margin-bottom: 0.45rem;
  white-space: nowrap;
}

.footer-brand {
  font-family: var(--font-sans);
  font-size: 0.75rem;
  font-weight: 600;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--text);
  margin-bottom: 0.75rem;
}

.footer-desc {
  font-size: 0.9rem;
  color: var(--text-muted);
  max-width: 380px;
  line-height: 1.7;
}

.footer-links h4 {
  font-family: var(--font-sans);
  font-size: 0.68rem;
  font-weight: 600;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--text-light);
  margin-bottom: 0.75rem;
}

.footer-links ul {
  list-style: none;
}

.footer-links li {
  margin-bottom: 0.4rem;
}

.footer-links a {
  font-family: var(--font-sans);
  font-size: 0.8rem;
  color: var(--text-muted);
}

.footer-disclaimer {
  font-family: var(--font-sans);
  font-size: 0.7rem;
  color: var(--text-light);
  line-height: 1.6;
  padding-top: 1.5rem;
  border-top: 1px solid var(--border-light);
}

/* --- Animations --- */
.fade-in {
  opacity: 0;
  transform: translateY(16px);
  transition: opacity 0.6s ease, transform 0.6s ease;
}
.fade-in.visible {
  opacity: 1;
  transform: translateY(0);
}

/* --- Responsive --- */
@media (max-width: 768px) {
  html { font-size: 16px; }
  h1 { font-size: 2rem; }
  
  .site-nav { display: none; }
  .site-nav.open {
    display: flex;
    flex-direction: column;
    position: absolute;
    top: var(--header-h);
    left: 0;
    right: 0;
    background: var(--bg);
    padding: 1.5rem 2rem;
    border-bottom: 1px solid var(--border);
    gap: 1rem;
  }
  .nav-toggle { display: block; }

  main { padding-left: 1.2rem; padding-right: 1.2rem; }

  .stats-grid {
    grid-template-columns: repeat(2, 1fr);
  }
  .stat-cell:nth-child(2) { border-right: none; }

  .solver-container {
    grid-template-columns: 1fr;
    min-height: 50vh;
  }
  .solver-sidebar { order: -1; }

  .footer-grid {
    grid-template-columns: 1fr;
    gap: 2rem;
  }

  .hero-actions { flex-direction: column; }
  .btn { text-align: center; }
}

@media (max-width: 480px) {
  h1 { font-size: 1.7rem; }
  .stats-grid { grid-template-columns: 1fr; }
  .stat-cell { border-right: none; border-bottom: 1px solid var(--border-light); }
  .stat-cell:last-child { border-bottom: none; }
}

/* --- Live Solver Toolbar & Badges --- */
.solver-toolbar {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 0.75rem 1rem;
  background: #111418;
  border-bottom: 1px solid #23272e;
  font-family: var(--font-mono);
  gap: 1rem;
  flex-wrap: wrap;
}

.status-badge {
  font-size: 0.75rem;
  padding: 0.35rem 0.75rem;
  border-radius: 4px;
  background: #1b2028;
  color: #8b949e;
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  white-space: nowrap;
}

.status-badge.live-active {
  background: rgba(46, 160, 67, 0.15);
  color: #3fb950;
  border: 1px solid rgba(46, 160, 67, 0.3);
}

.status-badge.demo-active {
  background: rgba(210, 153, 34, 0.15);
  color: #d29922;
  border: 1px solid rgba(210, 153, 34, 0.3);
}

.status-dot {
  width: 8px;
  height: 8px;
  border-radius: 50%;
  display: inline-block;
  flex-shrink: 0;
}
.status-dot.green {
  background: #3fb950;
  box-shadow: 0 0 6px #3fb950;
}
.status-dot.yellow {
  background: #d29922;
}

.solver-controls {
  display: flex;
  gap: 0.5rem;
  align-items: center;
}

.control-btn {
  background: #21262d;
  color: #c9d1d9;
  border: 1px solid #30363d;
  padding: 0.4rem 0.85rem;
  font-size: 0.75rem;
  font-family: var(--font-mono);
  border-radius: 4px;
  cursor: pointer;
  white-space: nowrap;
  transition: all 0.2s ease;
  display: inline-flex;
  align-items: center;
  justify-content: center;
}
.control-btn:hover {
  background: #30363d;
  color: #fff;
}
.control-btn.stop:hover {
  background: #da3633;
  color: #fff;
  border-color: #f85149;
}

.solver-disease-grid {
  display: flex;
  flex-direction: column;
  gap: 0.4rem;
  margin-top: 0.5rem;
}

.solver-disease-btn {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 0.5rem 0.75rem;
  background: var(--bg-card);
  border: 1px solid var(--border-light);
  border-radius: 4px;
  font-family: var(--font-sans);
  font-size: 0.78rem;
  color: var(--text-muted);
  cursor: pointer;
  text-align: left;
  transition: all 0.2s ease;
}
.solver-disease-btn:hover {
  background: #fff;
  color: var(--text);
  border-color: var(--teal);
}
.solver-disease-btn.active {
  background: var(--teal);
  color: #fff;
  border-color: var(--teal);
}
.solver-disease-btn.active .btn-gene {
  color: rgba(255, 255, 255, 0.8);
}
.btn-gene {
  font-family: var(--font-mono);
  font-size: 0.7rem;
  color: var(--text-light);
}